·944·中国药理学通报ChinesePharmacologicalBulletin2007Jul；23(7) tis in rats【JJ．ChinJRheumatol，2002，6(5)：331—4ChenQ，WeiW．Effects and mechanisms ot glucosides of chaenome]es speciosaOil collagen induced arthritis in rats[J]．托Immunopharmacol，2003，3(3)：593—608．戴敏，魏伟，汪倪萍，等．木瓜苷对佐剂性关节炎的治疗作用[J]．中国药理学通报，2003，19(3)：340—4．DaiM，WeiW，WangNP，et a1．Therapeutic effect of glucosides of chaenomeles speeiosa011 adjuvant in rats[J]．ChinPharmacolBull．2003，19(3)：340—4．张玲玲，魏伟，严尚学，等木瓜苷对小鼠胶原性关节炎的预防作用及初步机制[J]．中国药理学通报，2004，20(1)：95—100．ZhangLI一，WeiW，YahSX，et a1．Prophylactic effects of gluco— sides of chaenonleles speeiosa on collagen—induced arthritis in mice[J]．ChinPharmacolBull，2004，20(1)：95一loo．WangNP，DaiM，WangH，et a1．Antinocieeptive effect of glueo— sides of chaenomeles speeiosa[J]．Chin．，PharmacolToxicol，[9][9][10][10]2005，19(3)：169—74．丁长海，徐叔云，熊祖应，等．免疫性关节炎模型的制备[M]／／徐叔云，卞如濂，陈修主编药理实验方法学，3版，北京：人民卫生出版社，2002：920．DiIigCH，XuSY，XiongZY，el a1．Preparation ofthe model ofim munological arihritis[M]／／XuSY，BianRL，Chen x to edit．TechnoloKy of pharmacological experiment，3 rd ed，BeiJing：People’ sMedicalPul)lishingHouse，2002：920．刘辉丰编．临床免疫学和免疫检验实验指导(供医学检验专业用)[M]，第2版，JI；．qC：人民卫生出版社，2003：50—2．1血lH…edit．Laboratory pro(。rdure o，Clini(。al inununology and im，7111nological laboratory(、5,r medical laboratorySpecial)[M]，2nd ed，BeiJing：F'eople’sMedicalPublishingHouse，2003：50—2．HomandbergGA．Potential regulation of eartilage metabolism in osteoarthritis by fibronectin fragments[J]．FrontBiosci，1999，4：7l3—30Down-regulation effect of glucosides of cheanomeles speciosa on the levels of serum antibodies in rats with adjuvant arthritisCHENYin，WEIWei，WUHong，TANGLi—qin，WANGXiao—yu，YANGYu—qing(Institute of c胁dealPharmacology，AnhuiMedicalUniversi0：K吖Laboratory ofAntiittJlamnlator)一immunopharmacology inAnhuiProvice；Key l』zboratory ofResearch&Development ofChineseTraditionalMedicin,e inAahuiProvice．EngineeringTechnologyResearchCentre ofA，甜泐乒nmm“胁可一immunizationDrugs of l／niversities inAnhuiPm{『1ince，Hefei，China)Abstract：AimTo study the effects of glucosides ofGTW(40 mg·kg一)wet‘e given by intragastric admin— cheanomeles speciosa(GCS)on the levels of sel3．1111 an— istration for8(1ays fr()Ill the17 th day after immuniza— tibodies in rats with adjuvant arthritis．MethodsSD rats were divided randomly into six groups，including normal，model，GCS(30，60，120 mg·kg“)attd glu— cosides of tripterygium wifol‘dii(GTW)groups．Corn— pleteFreund’s adjuvant was used to induceAA in rats．The level of circulating intmune complexes in seru m was deternfined byPEG6000 assay，while the levels of anti—CⅡantibody．and anti—TB antibody in serum were measured by enzyme—linked immunosorbent assay(ELISA)．ResultsGCS(30，60，120 nag·kg“)and tion．GCS(60，120 mg·kg“)reduced the levels of circulating immuneCOtltplexes，anti—C1I antibody，and anti—TB antibody in serum in rats with adiuvant arthri— tis．ConclusionsGCS down regulates the1evels of se— runl antibodies in rats with adiuvant arthritis，which may be relate(1 to its efficacy in the tt-eatment of rats withAA．Key words：glucosides of cheanomeles speciosa；adju— vant arthritis；atttibody中国药理学通报0．492药学学报0．．5ActaPharmacologicaSinica0．4929．5中国药学杂志0．299药物分析杂志未进入前300名中国药科大学学报0．未进入前300名ActaPharmacologieaSinica已成为仝英文喇际性SCI核心期刊——《巾国药理学通报》编辑部注 b№№口一哆

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